introduction: d-galactose (d-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. in the present study, we selected crocin, the main constituent of crocus sativus l. (saffron), against d-gal cytotoxicity in human neuroblastoma sh-sy5y cells. materials and methods:  cells were pretreated with crocin (25-500 µm) for 24 h and then exposed to d-gal...

Abbreviations: NPC: Nasopharyngeal Carcinoma; NACT: Neoadjuvant Chemotherapy; 5y-OS: 5-Year Overall Survival; 5y-DFS: 5-Year Disease-Free Survival; 5y-RFS: 5-Year Local-RecurrenceFree Survival; 5y-MFS: 5-Year Distant-Metastasis-Free Survival; IMRT: Intensity-Modulated Radiation Therapy; CCT: Concurrent Chemotherapy; HN-MRI: Magnetic Resonance Imaging of Head and Neck; G3/4: Grade 3 To 4; CTCAE ...

Fibroblast growth factor (FGF) has been shown to protect tissue damage in animal models of cerebral and myocardial ischemia. The cellular and molecular mechanisms of FGF effects have not been fully defined. In the present study, we have investigated the effect of FGF homologs on nitric oxide (NO)-mediated neuronal cell death. Addition of NO donor S-nitroso-N-acetylpenicillamine (SNAP) to cultur...

In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-year overall survival rate (5Y-OS) of the ONC(+) and ONC(-) groups. The 5Y-RFS...

Apolipoprotein E (apoE) is associated with the two hallmarks of Alzheimer's disease: A beta deposits and neurofibrillary tangles. ApoE synthesis was detected in astrocytes by in situ hybridization but was not detected in neurons. Nevertheless, different studies on apoE immunoreactivity reported the presence of apoE in neurons of Alzheimer, control, and necrosis pontisubicular brains. In this st...

Complete disappearance of colorectal liver metastases (CLM) after chemotherapy is considered a good prognostic factor survival, but the presence residual tumoral cells arrives to 80% and recurrence rate 75% patients. Nowadays, management these patients still controversial. The aim this study evaluate impact different onco-surgical strategies in missing (MM) for who undergo curative surgery. Thi...

BACKGROUND Due to the protracted natural history of the clinical progression of prostate cancer, biochemical recurrence (BCR) is often used to compare treatment modalities. However, BCR definitions and posttreatment prostate-specific antigen kinetics vary considerably among treatments, calling into the question the validity of such comparisons. OBJECTIVE To analyze prostate cancer-specific mo...

BACKGROUND: GSK-3 , has been shown to regulate APP cleavage resulting in the increased production of A and the inhibition of the GSK-3 reduced the amyloid beta induced neurotoxicity in several studies. OBJECTIVE: This study was designed to investigate the GSK-3 inhibitory effects of 6-gingerol and 6-shogaol the major components ofZingiber officinale could be able to recover the SHSY-5Y cells fr...

The aim of this study was to retrospectively evaluate the effect of adding CPT-11 to postoperative chemotherapy for stage III colorectal cancer. The subjects were 94 patients, including 60 in stage IIIa (or=4 positive nodes), who underwent curative resection. The clinical outcome was compared between patients receiving 5-FU/LV plus CPT-11 (FLC group)...

BACKGROUND This study provides estimates of population-based relative survival in Spain for nine major cancers and reports results on cancer survival by region, gender and age group. PATIENTS AND METHODS Our analysis covered eight Spanish regions, namely, Basque Country, Navarre, Girona, Tarragona, Castellón, Albacete, Murcia and Granada, and included patients with cancer of the colon, rectum...